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The Wegovy SmPC notes that semaglutide causes delayed gastric emptying, which may impact the absorption of oral medications
E -values, following VanderWeele and Dings approach, estimated the minimum strength of association needed by unmeasured confounders to fully explain observed associations, addressing potential biases from unmeasured confounding 53,54
The FDA prescribing information for GLP-1 receptor agonists, including semaglutide, notes an increased risk of acute gallbladder disease (cholelithiasis, cholecystitis), which can present with jaundice and elevated liver enzymes that might be mistaken for direct liver injury
Hematoxylin and eosin (H&E) staining, along with Nissl body labeling, were utilized to assess neuronal integrity