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Obesity reviews: an official journal of the International Association for the Study of Obesity , 17 (10), 970976

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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

Beyond vitamin C, researchers say other deficiencies could also pose risks

Going below 1,500 risks nutrient deficiency, excessive fatigue, and metabolic adaptation that will ultimately slow weight loss