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5 Regulatory mechanisms of glucose metabolic reprogramming 5.1 NRG1/ErbB signaling pathway and regulation of cardiac metabolic status At the regulatory level, in models of cardiac injury and regeneration, activation of NRG1/ErbB2 signaling has been shown to induce a metabolic shift in cardiomyocytes from fatty acid oxidation toward glycolysis, providing readily available energy and biosynthetic precursors to support cell proliferation and tissue repair

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At one year, patients with moderate PAD who were started on GLP-1 RAs had fewer major adverse limb events (MALE) (0.8% vs 1.5%), major adverse cardiac events (MACE) (25.4% vs 29.3%), and decreased risk of hospitalizations (17.9 vs 26.8%)

GLP-1 weight loss is up to 35% muscle mass loss GLP-1 weight loss can be 20% to 35% loss of lean tissue instead of fat