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A downside was that food no longer brought the same satisfaction or excitement as before

After the end of the treatment period, the rats were injected with ketamine and xylazine to make them anesthetized and ready for sacrifice 4

Lyophilized peptide is stable at room temperature for shorter periods and refrigerated for longer

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In contrast, transient interactions between the exendin-P5 N-terminus and TMD are clearly important for agonism, with the majority of residues within this cavity being required for eliciting cAMP signalling (Figures 4-5, Supplemental Figure 10)