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Pernicious anaemia or malabsorption disorders typically require intramuscular hydroxocobalamin 1,000 g three times weekly initially, then maintenance doses every 23 months

Have not had success with diet and exercise alone

Chronically low insulin sensitivity, also known as insulin resistance, means your insulin cannot efficiently shuttle glucose from your bloodstream to your cells

In its coenzyme role, NAD+ accepts electrons from metabolic substrates during glycolysis, the TCA cycle, and beta-oxidation of fatty acids, becoming NADH

Discuss any persistent side effects with your GP or diabetes specialist nurse to develop personalised strategies for optimising your treatment experience