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1 Tirzepatide 15 mg: -11.2 kg average weight loss Injectable semaglutide 1 mg: -5.7 kg average weight loss HbA1c: -2.30% with tirzepatide 15 mg vs -1.86% with semaglutide 1 mg Rybelsus 14 mg (the highest available oral dose) produces roughly equivalent blood levels to injectable semaglutide 0.5-1.0 mg per week, which is at or below the injectable dose tested in SURPASS-2

Reduced joint pain allows more comfortable movement and activity

Even though each drug has different FDA-approved usages, they are all often used off-label for blood sugar management and weight reduction, regardless of whether thats the individual drugs FDA-approved use case

Endoscopy International Open, 13, a25501468

In clinical trials, patients lost an average of 15% of their body weight