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New drugs like Prolonix (Phase III trials) mimic amylin, showing 25% greater craving reduction than GLP-1 agonists alone

For the first time in our 16 years of analysis, obesity has displaced oncology as the largest contributor to late-stage pipeline value, increasing exposure to therapeutic area-specific shocks

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Late-day dosing also risks mild insomnia in B12-sensitive individuals because methylcobalamin can interfere with melatonin synthesis when taken within 6 hours of sleep

Kupffer and stellate cells Kupffer cells, the largest population of tissue-resident macrophages, reside within the sinusoids and maintain continuous interaction with gut-derived particles [43]