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It should definitely be tried before considering a second surgery. Avignon and colleagues recruited 111 adults with severe obesity, defined as having a BMI of 40 kg/m 2 or higher, who received semaglutide 2.4 mg once weekly for 24 weeks from April to October 2022

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Semaglutide falls in the middle range, more robust than some large proteins but more sensitive than small cyclic peptides

Their investigation raised serious concerns about the increased risk of gastrointestinal injuries and questioned whether drug manufacturers had adequately disclosed risks to patients and healthcare providers

Animal reproduction studies have been conducted with tirzepatide in rats and rabbits