Another FIN with a distinct mechanism of action in inducing ferroptosis, RSL3 11 , had similar differential ferroptosis induction in wild-type and IRE1-null MDA-MB-231 cells, suggesting that the effect of IRE1 on ferroptosis sensitivity is not limited to erastin or cystine starvation-induced ferroptosis (Supplementary Fig
INTRODUCTION Glucagon-like peptide (GLP-1) receptor agonists are an emerging and increasingly popular class of medications used for the treatment of type 2 diabetes mellitus and, more recently, obesity
The relationship between these two compounds is complex
Handling Lyophilised research peptide vials should be stored, logged, and handled using appropriate laboratory procedures and chain-of-custody records
Notably, addition of hemin or pyruvate, a source for NAD+ did not impact these growth phenotypes, suggesting that amelioration of heme defect or respiration inhibition is not sufficient to overcome anti-proliferative effects of mitochondrial GSH depletion (Extended Data Fig