Semaglutide has been structurally modified to resist degradation by the enzyme DPP-4 and to bind to albumin, extending its half-life from approximately two minutes for natural GLP-1 to about one week
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In a country with a well-documented obesity epidemic, Wegovy and other members of a new type of weight-loss drug are highly effective: In clinical trials, people on Wegovy typically lose 15% of body weight, and a similar medication, retatrutide, has shown up to 24% weight loss
That does not mean retatrutide should be framed as unsafe
It is important since poor diet, ageing, intense exercise, alcohol, overuse of antibiotics, etc, can deplete the antioxidant from the body