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Free copper is extremely reactive through Fenton chemistry, and it stimulates the secretion of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-4, and tumor necrosis factor (TNF) in both the brain and the blood (Figure 3 is a schematic of the processes by which impaired copper homeostasis can lead to neurodegenerative disease, and the hypothesis that copper trapping in plaque regions may be protective
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One of the conclusions we could extract is that patients in the former subgroup (high IgE plus high HLA-DR) are higher responders to the ozone therapy than the another one
Anais da Academia Brasileira de Ciencias, 92 (4), e20191371
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