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Fritz IB, McEwen BS

Gut feelings: the emerging biology of gutbrain communication

The kidneys (in particular, the proximal tubules) require a significant amount of energy in the form of adenosine tri-phosphate (ATP) in order to achieve solute reabsorption, protein synthesis and degradation, and regulation of glomerular filtration required to maintain homeostasis [10]

Current management strategies include foundational interventions like calorie restriction and lifestyle modification, which are shown to improve MASLD treatment outcomes by addressing the root metabolic cause

More significant improvement in cardiovascular risk factors associated with obesity