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These receptors are widely distributed throughout the central nervous system and peripheral tissues, mediating diverse physiological functions including pigmentation, energy homeostasis, sexual function, inflammation, and cardiovascular regulation

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Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans

The growing body of research reinforcing the impact of antibiotic consumption on disrupting microbial communities in the gut has encouraged the discovery of novel compounds that can alleviate such alterations