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The pKas of the compound are 10.3,7.8, and 6.2.[1] Synthesis of Ipamorelin In particular, ipamorelin was prepared from a total of 4.53 g of the peptide resin Boc-Aib-His (Trt)-D-2Nal-DPhe-Lys (Boc)-NH-resin according to the Fmoc strategy on an Applied Biosystems 431A peptide synthesizer in two identical runs (to obtain sufficient material) in 1 mmol scale using the FastMoc UV protocols supplied by the manufacturer, that employ HBTU mediated couplings in NMP and UV monitoring of the deprotection of the Fmoc protection group

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The aorta has the greatest elastin content within the arterial system and thus performs the important function of absorbing the pressure of systole and releasing it consistently in diastole so that pressure peaks can be dissipated and coronary perfusion can be increased