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Age considerations include lack of approval for individuals under 18

Although there is evidence that prepro-TRH 178-199 can inhibit both basal and CRH-stimulated ACTH release in AtT-20 cell lines and rat anterior pituitary cells (136,137), other investigators have not been able to confirm this (138)

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Deng et al., 2013) have several limitations (i.e., local application, carrier addition, and weak and uncertain peptide activity of its own (Seiwerth et al., 2018)), delaying practical realization of the growth factor healing concept