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Notably, reducing environmental L-serine levels has been shown to enhance natural killer (NK) cell function, thereby improving the efficacy of PD-1 immunotherapy ( 4.2.6 Lung adenocarcinoma PHGDH expression is particularly prominent in lung adenocarcinoma, closely associated with enhanced cell proliferation and migration, and maintains redox homeostasis by regulating glutathione (GSH) and pyrimidine synthesis ( 4.2.7 Acute myeloid leukemia Acute myeloid leukemia (AML) cells, especially leukemia stem cells, are highly dependent on the SSP maintained by the m6A-IGF2BP3 axis

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Are receiving chemotherapy or other antioxidant therapies

Cancer 14 , 419429 (2014)