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10.1016/j.jalz.2019.01.010 9 AmaseneM.BesgaA.EcheverriaI.UrquizaM.RuizJ

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After confirming that the concentration of NADPH in our lysates was within the linear detection range of the assay (Fig 3A), we treated LPS-stimulated (6 h) RAW264.7 Ms with 2-DG and diamide and quantified NADPH kinetics by obtaining lysates at 5-minute intervals for a total of 25 minutes (Fig 3B)

This indicates a systemic failure to properly transport and utilize lipid fuels

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