(12(1)):74 doi:10.1186/s13643-023-02238-w
The fixed track here just won't let that happen
Prevalence Heightened intestinal permeability has been demonstrated in the following conditions: Autoimmune Diseases: Celiac disease, type 1 diabetes, autoimmune hepatitis, multiple sclerosis, systemic lupus erythematosus and several other forms of autoimmunity have been linked to intestinal permeability syndrome and excessive bacterial translocation (ref) Psychiatric Disorders: Depression, anxiety, bipolar, schizophrenia (ref) Chronic Kidney Disease and Heart Failure (ref) Inflammatory Bowel Diseases: Conditions like ulcerative colitis and Crohns disease exhibit abnormal gut barrier function with increased intestinal permeability (ref) Functional Gastrointestinal Disorders: Irritable bowel syndrome (IBS) and functional dyspepsia (FD) and small intestinal bacterial overgrowth (ref) Metabolic Disorders: Obesity, metabolic syndrome and diabetes (ref) What causes Leaky Gut Syndrome
Fittingly, in cultured astrocytes Nagaraja and Brookes (1998) showed that channel- and NKCC1-mediated uptake together accounted for an uptake, which was similar in magnitude to the glutamate uptake in similar cultures
The precursor-versus-direct distinction sits underneath this argument
