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[13] The reasons for this positive selection are not known, but it has been hypothesized that elevated concentrations of acetaldehyde may have conferred protection against certain parasitic infections, such as Entamoeba histolytica

Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of a randomized, double-blind, placebo-controlled trial treatment of interstitial cystitis/painful bladder syndrome with low-dose sildenafil

Furthermore, supplementation with riboflavin results in marked lowering of homocysteine concentrations specifically in individuals with the variant MTHFR 677TT genotype (15)

This is a more concentrated solution, meaning you'd use a smaller volume for each dose

Scientific reports 13(1), 2023