In vivo cigarette smoke (CS) exposure Male C57B/6 two month old mice were obtained from Jackson's laboratory (Bar Harbor, ME)
Cao nhn sm t n: H tr tnh trng sm da do rm nng, chy nng, gim mn trng c, pht ban trn da, tng tit b nhn ng thi lm gim tnh trng rng tc, gy tc, ri lon dinh dng mng
The astrocytes modify their phenotype, adopting a cellular morphology characterized by hypertrophic nuclei and cell bodies with distinct long and thick processes with increased glial fibrillary acidic protein (GFAP)
Similarly, inhibitors of lysyl oxidase-like enzymes (LOXL2/LOXL3), such as PXS-5153A, reduce collagen crosslinking and liver stiffness in preclinical settings (180)
10.1142/S0192415X21500762 21 Centers for Disease Control and Prevention