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Detachment of cytochrome c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT
Neuron 56 , 5865 (2007)
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At the same time, they can also promote cancer progression by releasing immunosuppressive signals, such as 8-OHdG and KRAS proteins that cause TAMs to differentiate into M2 phenotypes, as well as PGE2 that inhibits the functions of NK cells, DCs, and CD8(+) T cells (210212)
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