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Chung Y
To investigate whether albumin could be engineered to evade L585 cleavage and the resulting reduction in FcRn binding, we constructed a panel of 18 full-length 585-engineered human albumin variants, in which the C-terminal leucine residue was substituted with each of the other naturally occurring amino acids, except for cysteine (Fig
[12] [13] The medication is indicated for adults with type 2 diabetes as an adjunct to diet and exercise, and for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbid condition
Mottillo EP, Granneman JG
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