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(C): Photomicrograph of T.S in the liver of Tadalafil group treated rats showing: Loss of the normal hepatocytic architecture, vacuoles, degeneration of hepatocytes with pyknotic nuclei (black square& black arrow), fibrosis and congestion around the portal area and (black circle), dilation and congestion of portal vein (blue dotted arrow), congestion in hepatocytes and blood sinusoids (black dotted arrow), binucleated hepatocyte (green dotted arrow)