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This may explain why some patients do not respond to optimal levels of 6-TGNs or suffer adverse effects from high levels of meMPs (Wright et al., 2004

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Ginsenoside Rg1 prevents cognitive impairment and hippocampal neuronal apoptosis in experimental vascular dementia mice by promoting GPR30 expression

10.1038/s41398-017-0031-4 494 YangJ.-Z.ZhangK.-K.LiuY.LiX.-W.ChenL.-J.LiuJ.-L.et al

Hyperglycaemia progressively impairs these transporters, accelerating beta-cell apoptosis and microvascular complications