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25% savings is an average annual savings amount and varies based on utilization.

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Merck began trials of the HMG-CoA reductase inhibitor lovastatin in 1980, and won a historic approval in 1987-- showing the medication produced robust reductions in LDL levels

The key consideration is managing potential side effects rather than avoiding concurrent use altogether, and most patients tolerate both medications without significant problems when appropriate supportive measures are implemented

I dug through the trial numbers and the pricing