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They may have underreported minor discomforts that did not meet thresholds for adverse event classification

The prevalence of anemia in overweight and obesity (OWOB) was 5.2% in boys and 11.7% in girls

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Moreover, chronic oxidative stress generated through CYP2E1 induction was shown to interfere with the insulin signaling cascade via a decrease in tyrosine phosphorylation of insulin receptor substrates 1 and 2