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Finally, 79 participants in a large, multi-ethnic study of atherosclerosis who were also taking metformin had significantly higher levels of lac-phe circulating in their blood than those who were not taking the drug

In support of this hypothesis, hormone replacement therapies (HRT) that include estradiol have been shown to improve insulin sensitivity and lower blood glucose levels (164166)

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However, using the two together increases the risk of side effects, including the risk of dangerous ketone buildup, says Jefferey Chester, DO, Medical Director, The Ohana Treatment Center