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These pathways are both serotonergic (eg, rostral ventral medulla) and noradrenergic (eg, dorsolateral pontine tegmentum), converging into the dorsal lateral funiculus, which synapse in rexeds laminae I, II and V in the spinal cord dorsal horn

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This study concluded that the peripheral and the central GLP1 systems are therefore separate entities, which independently act to reduce food intake

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