Infection points of the obesity indication were the FDA approval of high-dose semaglutide (Wegovy) in June 2021 and tirzepatide (Zepbound) in November 2023 specifically as chronic weight management drugs, where both drugs showed unprecedented efficacy in weight reduction, averaging 15-22% of baseline body weight in clinical trials
doi:10.1016/j.ejphar.2003.08.054
Dietary nano-manganese supplementation enhances intestinal integrity, muscle traits, and tight junction protein expression in broilers
Most common effects are gastrointestinal - nausea, constipation, diarrhoea, and stomach discomfort - particularly during dose escalation
[8] In other words, where cagrilintide is a research-stage candidate, tirzepatide is an approved medicine with the safety labeling that approval brings