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Copper complexes, such as the Hinokitiol copper complex, inhibit the deubiquitinase activity of certain proteasomes, contributing to ATF4-associated ER stress and subsequently to paraptosis [147]

This creates a reinforcing feedback loop that not only sustains tumor progression but also further facilitates immune evasion and the development of resistance to both chemotherapy and immunotherapy [105]

This is because it bypasses many physiological systems and enzymatic degradation therefore nothing can disturb its metabolism and active ingredients

Chakrabarti/Campbell Am J Case Rep 2026

Sementara topical skincare bekerja lebih spesifik pada lapisan kulit di area yang diaplikasikan