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Contrave : Seizures: Bupropion, one of the ingredients in Contrave , lowers the seizure threshold, increasing the risk in those prone to seizures

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In addition, the mRNA and protein levels of SESN2 in the PA group were lower than those in the control group, and liraglutide treatment alleviated this decrease in SESN2 expression caused by PA in a dose-dependent manner (Fig