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These should be used with caution if you have high blood pressure, heart disease, diabetes, or thyroid problems

Your stomach should be empty, but you can take a small sip of water to get the pill down

While semaglutide provides substantial metabolic benefits, its GI AEs, most notably nausea, vomiting, diarrhoea, and constipation, can compromise treatment adherence, particularly during the early dose-escalation phase

This phase 3b trial evaluates mirikizumab combined with tirzepatide versus mirikizumab with a placebo in adult participants with moderately to severely active CD and comorbid obesity (111)

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