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Note: Decisions about treatment are for both the prescriber and the person to jointly consider during the consultation

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Weight loss under the action of GLP-1RA is not only caused by acting on the hypothalamus or parasympathetic nervous system, thereby inhibiting appetite and delaying gastric emptying, but also by acting on white and brown adipocytes

The review documents the dose-response relationship for pramlintide's glycemic and weight effects, with the 120 microgram pre-meal dose providing optimal benefit in type 2 diabetes

For a more focused comparison of oral and injectable formats, see Rybelsus vs