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On the other hands, great amounts of drug cause gastrointestinal distress that is not always well tolerated by patients

It might be that the lower SOD activity of positive animals reflects excessive consumption of the enzyme (antioxidant consumption hypothesis) to buffer increased superoxide production rather than an inhibitory effect (antioxidant inhibition hypothesis) of viral infection on the enzyme 35

Moreover, none of the included studies conducted systematic analyses of small moleculeprotein interactions, and the pharmacokinetic relevance of the doses used in vitro versus in vivo studies remains largely unaddressed

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