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We have previously reported in rats that acute infusion of GLP-1 potently increases skeletal muscle microvascular perfusion in both acute (lipid infusion) and chronic (high fat diet feeding) insulin resistant states

Conclusions In this multicenter, retrospective, observational study, semaglutide was associated with lower 3-year risks of all-cause death, acute myocardial infarction, stroke, and acute heart failure compared with dulaglutide in patients with type 2 diabetes