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It is also helpful to reduce lower back or neck pain, pain in sciatic nerve and Carpel Tunnel syndrome

10,11,12,13,14,15,16,17 The clinical findings observed in this small group of patients served as a basis for establishing diagnostic criteria, with severe skin fragility, sagging, and redundant skin as major clinical criteria, and a soft, doughy skin texture, easy bruising, premature rupture of fetal membranes, and large hernias (umbilical, inguinal) as minor criteria

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Samples were then centrifuged at 15,000 g for 5 min to pellet cellular debris, and the supernatant was collected