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doi:10.1126/sciadv.1500980

Studies have found that NNMT expression gradually rises during adipocyte differentiation, and its enhanced activity promotes the differentiation of preadipocytes into mature adipocytes by depleting NAD and inhibiting the SIRT1 longevity pathway

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(2000) showed that daily oral administration of 500 g/kg body weight to obese Zucker rats for 19 days resulted in over 50% reduction in body weight gain (15.8 0.6 g vs

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