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Its efficacy and the severity of adverse effects depend on the right dosage. How to Administer Injectable Semaglutide and Compounded Semaglutide Semaglutide and Compounded Semaglutide are administered as a once-weekly subcutaneous injection in the abdomen, upper arm, or thigh at any time of the day

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This explains why the mg dose is so much higher for the oral dosage form compared to the once-weekly subQ dosage form

Ohara M, Ogawa K, Suda G, Kimura M, Maehara O, Shimazaki T, Suzuki K, Nakamura A, Umemura M, Izumi T, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ohnishi S, Sakamoto N