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Based on the function of Tregs and their ability to induce cytokine immunosuppression, researchers consider treating AR by increasing IL-10, TGF-, and IgG4 levels and Treg cell counts to induce immune tolerance [105]

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Mechanistically, high-glucose-induced AGEs promote cuproptosis in cardiomyocytes by upregulating SLC31A1 expression, which drives pathogenic Cu accumulation [80]

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6 Challenges and future directions Clinical trials that employ the lifestyle changes and microbiota-based approaches discussed above are usually carried out in small cohorts