Animals fed on a selenium deficient diet exhibit a significant reduction of testicular GPx activity and an accompanying loss of germ cells from the germinal epithelium of the testes.16 Moreover, selenium administration prior to the creation of oxidative stress in the testes using the torsion/detorsion model (see later) to create ischemia-reperfusion injury, has been found to suppress lipid peroxidation and improve the histopathological profile.17 Small Molecular Mass Antioxidants In addition to the major ROS processing enzymes, the testes rely heavily on small molecular weight antioxidant factors for protection against oxidative damage
J Neurosci 40(45):8604-8617
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