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Considering the decreased NAD+ levels occurring in the GCs of PCOS patients, nicotinamide (NAM) and its metabolite N1-Methylnicotinamide (MNAM) have been shown to have therapeutic potential in PCOS (171, 172)

If you've completed 46 weeks at standard dosage without measurable body composition change, the issue is likely dietary (insufficient caloric deficit) rather than dosage insufficiency

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