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GLP-1 agonists can affect mood: a case of worsened depression on Ozempic (Semaglutide)

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P = 0.0028 for subjects with a nor-mal and abnormal Schilling test, respectively]

This is further supported by the inability of phlorizin to prevent glucose-induced GIP secretion in streptozotocin-treated, hyperglycemic mice, where complete blockage of GIP secretion is only achieved in these mice upon both phlorizin and K ATP channel activation (diazoxide) (Ogata et al., 2014)

Because daily calorie intake was not measured, they note that further research will be needed to better understand the biological mechanisms underlying these findings