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This can be due to different genetic mechanisms, such as deletion of the paternal chromosome 15q11-q13, maternal uniparental disomy for chromosome 15, abnormalities of the imprinting center, or translocations involving chromosome 15

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Routine bone density screening is not currently recommended for all patients taking GLP-1 receptor agonists, as there is insufficient evidence to support universal monitoring based solely on GLP-1 use