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Gastrointestinal symptoms have also been reported, including heartburn, abdominal pain, belching, nausea, vomiting, flatulence, constipation, and diarrhea (106)

Wegovy section 7.2 goes further, directing prescribers to monitor the effects of concomitant oral medications and to consider increased clinical or laboratory monitoring for drugs with a narrow therapeutic index or that require clinical monitoring

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More importantly, folinic acid can use alternative transport mechanisms (e.g., reduced folate carrier, RFC) to enter the brain, bypassing the blocked FR pathway