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Nat Immunol (2015) 16(5):44857.10.1038/ni.3153 103 KremerJMBlancoRBrzoskoMBurgos-VargasRHallandAMVernonEet alTocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year