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Reduced NAD+ levels impair mitochondrial function, leading to decreased ATP production and increased reactive oxygen species generation

However, it also has been found to be associated with insulin resistance syndrome including obesity, fat distribution, hypertension, dyslipidemia, and cardiovascular disease [48]

Its also unknown what doses would need to be prescribed for it to have a beneficial effect

QM/MM MD US simulations were performed in NVT ensemble at 300 K with a 250 kcal/(mol 2 ) force constant applied for the reaction coordinate

However, this association was not observed at the 50 mg dose, and the analysis was based on only two trials with limited sample sizes