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This means your travel case needs to maintain actual refrigerator temperatures, not just "below 86 degrees." A FRIO wallet alone is insufficient

doi: 10.1016/j.vaccine.2015.02.006 23 KimSHJungDIYangIYKimJLeeKYNochiTet al

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the latter become activated, leading to the expulsion of further inflammatory cytokines, nitric oxide and ROS that, in turn, damage neurons in the SNPC, leading to death

M.RothJ.et al (2005)