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Curiously, oxidized GAPDH interacts with RNA- and DNA-binding proteins, suggesting that these adaptation mechanisms may not be limited to alterations in enzyme activity [40]

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Intravenously: glutathione is used for preventing anaemia in patients undergoing haemodialysis, preventing renal dysfunction after coronary bypass surgery, treating Parkinsons disease, improving blood flow and decreasing clotting in individuals with atherosclerosis, treating diabetes, and preventing toxicity of chemotherapy

Therefore, further research is warranted to clarify the role of HSP70 in rIPC-induced renal protection, including its regulatory mechanisms and potential therapeutic implications (Figure 4)