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Doubled Mortality Rates in Breast Cancer Patients Using B12 In breast cancer patients , Vitamin B12 supplements during chemo have been linked to doubled mortality rates

Best published PK (Awosemo et al., 2021, rats): ~38% oral bioavailability, ~6 to 7 hr oral half-life

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The mechanism is not fully understood but it is believed that the increased intracellular glutathione levels and increased ROS 217 are closely coupled with the build-up of toxic lipid peroxides and consequent ferroptosis

Short-term use may be sufficient for acute oxidative stress, while chronic conditions may require longer or cyclical supplementation