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10.1111/j.1468-1331.2009.02917.x 81 MendietaL.GranadoN.AguileraJ.TizabiY.MoratallaR

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In some embodiments, the otic formulation or composition comprises between about 1% to about 3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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Besides, roFPs under physiological conditions are only sensitive to oxidative stress but not to any reductive stress because they completely transition to a fully reduced state once in the cytosol